For several years I ran Reason 5.0.1 on Linux under WINE, but the experience was always somewhat subpar. So I resorted to building a minimalist virtual machine that can be run under virt-manager/qemu-kvm under Linux to be able to make music more comfortably.
Reason 5 is now considered abandonware. This means you can use it for free. This video is about the virtual machine I put together so it becomes easy to start making music with Reason on Linux.
More information and download: https://jokingly.online/retrostudio